AJ Journal of Medical Sciences

Volume: 1 Issue: 1

  • Open Access
  • Review Article

Implications of Oral Candida Carriage in Clinical Practice - A Review

Tripthi Uchil1,5, Rachan Shetty2, Prajna Sharma3, Manjula Shantaram4, Pavan Chand Attavar5,∗

1Department of Microbiology, AJ Institute of Allied Health Sciences, NH-66, Kuntikana, Mangalore, Karnataka, India.
2Department of Medical Oncology, AJ Hospital and Research Centre, NH-66, Kuntikana, Mangalore, Karnataka, India.
3Department of Microbiology, AJ Institute of Medical Sciences and Research Centre, NH-66, Kuntikana, Mangalore, Karnataka, India.
4AJ Research Centre, NH-66, Kuntikana, Mangalore, Karnataka, India.
5Department of Microbiology, Srinivas Institute of Medical Sciences and Research Centre, Srinivas University, Mukka, Surathkal, Karnataka, India.

*Corresponding author. Pavan Chand Attavar: [email protected]
 

Year: 2024, Page: 6-11, Doi: https://doi.org/10.71325/ajjms.v1i1.1

Received: June 27, 2024 Accepted: Dec. 3, 2024 Published: Dec. 31, 2024

Abstract

Oral candidiasis is a fungal infection that affects the oral cavity. Candida species are commensal organisms that reside in the oral cavity, gastrointestinal tract and genitourinary tract of humans without causing harm under normal circumstances. However, disruptions in the host’s immune defence mechanisms or alterations in the local microbiota can lead to the overgrowth of these fungi resulting in infection. Oral candidiasis is one of the common manifestations seen in immunocompromised individuals specially in HIV and cancer patients undergoing treatment. Emergence of antifungal drug resistance is of serious concern owing to the associated morbidity and patient outcomes. This review article provides an in-depth knowledge of oral Candidiasis, risk factors, diagnostic approaches, management strategies and patient outcomes. Understanding oral Candidiasis is essential for both clinicians and researchers to prevent and manage Candida-associated oral infections.

Keywords: Candida, Oral cavity, Candidiasis, HIV, Chemotherapy, Radiotherapy

References

  1. Nagaraj T, Kongbrailatpam S, Mumtaz S, Mohiyuddin YS. Oral erythematous candidiasis: A case report. International Journal of Medical and Dental Case Reports. 2020;7(1):1–4. Available from: https://dx.doi.org/10.15713/ins.ijmdcr.147

  2. Taylor M, Brizuela M, Raja A. Oral Candidiasis. Treasure Island (FL). StatPearls Publishing. 2024.

  3. Rajendran R. Benign and malignant tumors of oral cavity. In: Textbook of oral pathology. (Vol. 7) 2011.

  4. Kumar BV, Padshetty NS, Bai KY, Rao MS. Prevalence of Candida in the oral cavity of diabetic subjects. Journal of the Association of Physicians of India. 2005;53:599–602. Available from: https://pubmed.ncbi.nlm.nih.gov/16190127/

  5. Lalla RV, Latortue MC, Hong CH, Ariyawardana A, Palumbo SD, Fischer DJ, et al. A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer. 2010;18(8):985–992. Available from: https://doi.org/10.1007/s00520-010-0892-z

  6. Bhat S, Nangia R, Sethi N, Ahmed J, Pasbola A. Oral Candidiasis a common manifestation of xerostomia and chronic renal failure: A report of two case series. Archives of Dental Research. 2023;13(2):126–130. Available from: https://doi.org/10.18231/j.adr.2023.025

  7. Tasso CO, Ferrisse TM, Oliveira AB, Ribas BR, Jorge JH. Candida species as potential risk factors for oral squamous cell carcinoma: systematic review and meta-analysis. Cancer Epidemiology. 2023;86. Available from: https://doi.org/10.1016/j.canep.2023.102451

  8. Naglik JR, Konig A, Hube B, Gaffen SL. Candida albicans-epithelial interactions and induction of mucosal innate immunity. Current Opinion in Microbiology. 2017;40:104–112. Available from: https://doi.org/10.1016/j.mib.2017.10.030

  9. Jham BC, Franca EC, Oliveira RR, Santos VR, Kowalski LP, Freire ARDS. Candida oral colonization and infection in Brazilian patients undergoing head and neck radiotherapy: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. . 2007;103(3):355–358. Available from: https://doi.org/10.1016/j.tripleo.2006.02.005

  10. Patel M. Oral cavity and Candida albicans: Colonisation to the development of infection. Pathogens. 2022;11(3):1–17. Available from: https://doi.org/10.3390/pathogens11030335

  11. Martins N, Ferreira IC, Barros L, Silva S, Henriques M. Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment. Mycopathologia. 2014;177(5-6). Available from: https://doi.org/10.1007/s11046-014-9749-1

  12. Yu D, Liu Z. The research progress in the interaction between Candida albicans and cancers. Frontiers in Microbiology. 2022;13:1–10. Available from: https://doi.org/10.3389/fmicb.2022.988734

  13. Ramla S, Sharma V, Patel M. Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients. Supportive Care in Cancer. 2016;24(6):2429–2436. Available from: https://dx.doi.org/10.1007/s00520-015-3035-8

  14. Prakash V, Singh R, Saurabh K, Kumar V, Kumar R, Kumar S, et al. Spectrum of chemo-radiotherapy induced fungal infection in head and neck cancer patients at tertiary care centre of Eastern India. Oral Oncology Reports. 2023;6:1–4. Available from: https://doi.org/10.1016/j.oor.2023.100039

  15. Debta P, Swain SK, Sahu MC, Abuderman AA, Alzahrani KJ, Banjer HJ, et al. Evaluation of candidiasis in upper aerodigestive squamous cell carcinoma patients-A clinico-mycological aspect. International Journal of Environmental Research and Public Health. 2022;19(14):1–12. Available from: https://doi.org/10.3390/ijerph19148510

  16. Kawanishi N, Hoshi N, Adachi T, Ichigaya N, Kimoto K. Positive effects of saliva on oral candidiasis: Basic research on the analysis of salivary properties. Journal of Clinical Medicine. 2021;10(4):1–11. Available from: https://doi.org/10.3390/jcm10040812

  17. Kheirollahi K, Moghadam SHH, Kabir G, Mehrjardi ZZ. Evaluation of distribution of different species of candida in cancer patients. Jordani biomedicine journal. 2019;7(2):39–48. Available from: http://dx.doi.org/10.29252/jorjanibiomedj.7.2.39

  18. Rebolledo CM, Sanchez MM, Bettín MA, Mosquera CH, Lozano GA. Oral candidiasis in patients undergoing cancer chemotherapy. Revista Cubana de Estomatología. 2020;57(1):56–69. Available from: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=97151

  19. Ferreira PMdV, Gomes MdCMF, ACSMA, et al. Evaluation of oral mucositis, candidiasis, and quality of life in patients with head and neck cancer treated with a hypofractionated or conventional radiotherapy protocol: a longitudinal, prospective, observational study. Head & Face Medicine. 2023;19(1):1–10. Available from: https://doi.org/10.1186/s13005-023-00356-3

  20. Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi O, Sanusi AA. Oral findings in chronic kidney disease: implications for management in developing countries. BMC Oral Health. 2015;15:1–8. Available from: https://doi.org/10.1186/s12903-015-0004-z

  21. Escarcega VO, Rui-Rodriguez MdS, Fonseca-Leal MdP, Santos-Díaz MA, Gordillo-Moscoso A, Nernández-Sierra JF, et al. Prevalence of Oral Candidiasis in Chronic Renal Failure and Renal Transplant Pediatric Patients. Journal of Clinical Pediatric Dentistry. 2008;32(4):313–317. Available from: https://doi.org/10.17796/jcpd.32.4.f53343t742150l73

  22. Molek M, Florenly F, Lister NE, Wahab TA, Lister C, Fioni F. Xerostomia and hyposalivation in association with oral candidiasis:a systematic review and meta-analysis. Evidence-Based Dentistry . 2022. Available from: https://doi.org/10.1038/s41432-021-0210-2

  23. Jeffery-Smith A, Taori SK, Schelenz S, Jeffery K, Johnson EM, Borman A, et al. Candida auris: a review of the literature. Clinical Microbiology Reviews. 2017;31(1):1–18. Available from: https://doi.org/10.1128/cmr.00029-17

  24. Egger NB, Kainz K, Schulze A, Bauer MA, FM, Carmona-Gutierrez D. The rise of Candida auris: from unique traits to co-infection potential. Microbial Cell. 2022;9(8):141–144. Available from: https://doi.org/10.15698/mic2022.08.782

  25. Deorukhkar SC, Saini S, Mathew S. Non-albicans Candida Infection: An Emerging Threat. Interdisciplinary Perspectives on Infectious Diseases. 2014;2014:1–7. Available from: https://dx.doi.org/10.1155/2014/615958

  26. Kordalewska M, Zhao Y, Lockhart SR, Chowdhary A, Berrio I, Perlin DS. Rapid and Accurate Molecular Identification of the Emerging Multidrug-Resistant Pathogen Candida auris. Journal of Clinical Microbiology. 2017;55(8):2445–2452. Available from: https://dx.doi.org/10.1128/jcm.00630-17

  27. Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, et al. Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses. Clinical Infectious Diseases. 2017;64(2):134–140. Available from: https://dx.doi.org/10.1093/cid/ciw691

  28. Lee WG, Shin JH, Uh Y, Kang MG, Kim SH, Park KH, et al. First Three Reported Cases of Nosocomial Fungemia Caused by Candida auris. Journal of Clinical Microbiology. 2011;49(9):3139–3142. Available from: https://dx.doi.org/10.1128/jcm.00319-11

  29. Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. Journal of Oral Microbiology. 2011;3(1):5771. Available from: https://dx.doi.org/10.3402/jom.v3i0.5771

  30. Sankari SL, Mahalakshmi K, Kumar VN. Chromogenic medium versus PCR–RFLP in the speciation of Candida: a comparative study. BMC Research Notes. 2019;12(1):681. Available from: https://dx.doi.org/10.1186/s13104-019-4710-5

  31. Clarkson JE, Worthington HV, Eden TOB. Interventions for preventing oral candidiasis for patients with cancer receiving treatment. Cochrane Database of Systematic Reviews. 2007;p. 3807. Available from: https://doi.org/10.1002/14651858.cd003807.pub3

  32. Taverne-Ghadwal L, Kuhns M, Buhl T, Schulze MH, Mbaitolum WJ, Kersch L, et al. Epidemiology and Prevalence of Oral Candidiasis in HIV Patients From Chad in the Post-HAART Era. Frontiers in Microbiology. 2022;13:844069. Available from: https://dx.doi.org/10.3389/fmicb.2022.844069

  33. Barrett JP, Vardulaki KA, Conlon C, Cooke J, Ramirez PD, Evans EV. A systematic review of the antifungal effectiveness and tolerability of amphotericin B formulations. Clinical Therapeutics . 2003;25(5):1295–1320. Available from: https://doi.org/10.1016/s0149-2918(03)80125-x

  34. Ostrosky-Zeichner L, Marr KA, Rex JH, Cohen SH. Amphotericin B: time for a new "gold standard" Clinical Infectious Diseases. 2003;37(3):415–425. Available from: https://doi.org/10.1086/376634

  35. Chen SCA, Sorrell TC. Antifungal agents. Medical Journal of Australia. 2007;187(7):404–409. Available from: https://doi.org/10.5694/j.1326-5377.2007.tb01313.x

  36. Mcguire TR, Trickler WJ, Smith LM, Vrana A, Hoie EB, Miller DW. Release of prostaglandin E-2 in bovine brain endothelial cells after exposure to three unique forms of the antifungal drug amphotericin B: role of COX-2 in amphotericin B induced fever. Life Sciences. 2003;72(23):2581–2590. Available from: https://experts.nebraska.edu/en/publications/release-of-prostaglandin-e-2-in-bovine-brain-endothelial-cells-af

  37. Lord AM, North TE, Zon LI. Prostaglandin E2, making more of your marrow. Cell Cycle. 2007;6(24):3054–3057. Available from: https://doi.org/10.4161/cc.6.24.5129

  38. Quindos G, Gil-Alonso S, Marcos-Arias C, Sevillano E, Mateo E, Jauregizar N, et al. Therapeutic tools for oral candidiasis: Current and new antifungal drugs. Med Oral Patol Oral Cir Bucal. 2019;24(2):e172–e180. Available from: https://doi.org/10.4317/medoral.22978

  39. Badiee P, Alborzi A. Susceptibility of clinical candida species isolates to antifungal agents by E-test, Southern Iran - A five year study. National library of medicine. Iranian Journal of Microbiology. 2011;3(4):183–188. Available from: https://pubmed.ncbi.nlm.nih.gov/22530086/

  40. Chongtham U, Athokpam DC, Singh RM. Isolation, Identification and Antifungal Susceptibility Testing of Candida Species: A Cross-sectional Study from Manipur, India. Journal of clinical and Diagnostic research. 2022;16(04):09–14. Available from: http://dx.doi.org/10.7860/JCDR/2022/55695.16248

  41. Maheronnaghsh M, Fatahinia M, Dehghan P, Teimoori A. Identification of candida species and antifungal susceptibility in cancer patients with oral lesions in Ahvaz, Southern west of Iran. Advanced Biomedical Research. 2020;30(9):1–7. Available from: https://doi.org/10.4103/abr.abr_214_19

  42. Makinen A, Nawaz A, Makitie A, Meurman JH. Role of Non-Albicans Candida and Candida Albicans in Oral Squamous Cell Cancer Patients. Journal of Oral and Maxillofacial Surgery. 2018;76(12):2564–2571. Available from: https://doi.org/10.1016/j.joms.2018.06.012

  43. Lyon GM, Karatela S, Sunay S, Adiri Y. Antifungal Susceptibility Testing of Candida Isolates from the Candida Surveillance Study. Journal of Clinical Microbiology. 2010;48(4):1270–1275. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC2849617/

  44. Bilal H, Hou B, Shafique M, Islam R, Khan MN, Khan RU, et al. Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis. Virulence. 2022;13(1):1573–1589. Available from: https://doi.org/10.1080/21505594.2022.2123325

  45. Pizzo G, Giuliana G, Milici ME, Gianreco R. Effect of dietary carbohydrates on the in vitro epithelial adhesion of Candida albicans, Candida tropicalis and Candida krusei. New Microbiology. 2000;23(1):63–71. Available from: https://pubmed.ncbi.nlm.nih.gov/10946407/

Copyright

© 2024 Published by Laxmi Memorial Education Trust. This is an open-access article under CC BY 4.0 license. (https://creativecommons.org/licenses/by/4.0/)

Cite this article

Tripthi Uchil, Rachan Shetty, Prajna Sharma, Manjula Shantaram, Pavan Chand Attavar. Implications of Oral Candida Carriage in Clinical Practice - A Review. AJ J Med Sci 2024;1(1):6–11

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