Volume: 2 Issue: 3
Year: 2025, Page: 134-137, Doi: https://doi.org/10.71325/ajjms.v2i3.2 5.41
Received: Aug. 20, 2025 Accepted: Aug. 28, 2025 Published: Nov. 13, 2025
Background: Prostate cancer is a major health burden, and new therapeutic agents from natural sources are urgently needed. Plant lectins, known for their selective binding to cancer cell surface glycans, show promising antiproliferative potential. This study investigates the in vitro effects of a bulb lectin from Scadoxus multiflorus on human prostate cancer cells. Methods: A purified lectin from Scadoxus multiflorus bulbs was evaluated against human prostate cancer cell lines. It’s cytotoxic and antiproliferative effects were measured using the MTT assay, while the scratch assay assessed its influence on cell migration. Data were analysed to establish its dose-dependent antiproliferative potential. Results: The MTT assay demonstrated that SmL significantly inhibited prostate cancer cell proliferation in a concentration-dependent manner after 48 h of treatment, with an IC₅₀ value of 51.36 µg. In contrast, SmL exhibited no appreciable cytotoxicity toward normal Human Embryonic Kidney (HEK293) cells, even at higher concentrations, indicating its selectivity for tumour cells. Furthermore, the scratch assay revealed that SmL effectively suppressed cancer cell migration. Conclusion: These findings suggest that the lectin from Scadoxus multiflorus bulbs (SmL) possesses selective antiproliferative activity against human prostate cancer cells by inhibiting proliferation and migration while sparing normal cells. SmL thus represents a promising natural candidate for further investigation as a potential therapeutic agent for prostate cancer.
Keywords: <I>Scadoxus multiflorus</I>, Bulbs, Lectin, Antiproliferative activity, Wound healing assay
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© 2025 Published by Laxmi Memorial Education Trust. This is an open-access article under CC BY 4.0 license. (https://creativecommons.org/licenses/by/4.0/)
M Meghana, G J Sathisha, E Sarathkumar, G T Ramya, N Anitha. In vitro Antiproliferative Effects of a Bulb Lectin from Scadoxus multiflorus (SmL) on Human Prostate Cancer Cells. AJ J Med Sci 2025;2(3):134-137