Volume: 2 Issue: 4
Year: 2025, Page: 170-176, Doi: https://doi.org/10.71325/ajjms.v2i4.25.91
Received: Nov. 13, 2025 Accepted: Dec. 27, 2025 Published: Dec. 31, 2025
Background and Aim: The current study explores the effects of zinc and L-carnitine supplementation on reproductive function in female albino mice. The study primarily focuses on growth of follicles and regulation of endocrine fertility. As previous studies have mentioned, both zinc and L-carnitine are crucial for reproductive health, this study explores the combined effect on reproductive hormonal regulation and ovarian follicle development. The aim of this study is to assess the impact of combined supplementation of zinc and L-carnitine on reproductive hormone levels and ovarian follicle development in female albino mice. Materials and Methods: Forty adult female mice were divided into four experimental groups. Control, Zinc (25 mg/kg/day), L-carnitine (0.5 mg/kg/day) and Zn + LC. Animals received the treatment for 30 days and follicle development, hormonal levels and histological changes in the ovarian tissues were assessed. Results: The zinc and L-carnitine supplementation gave rise to significant improvement in the ovarian follicles numbers along with a decrease in the abnormal follicles along with the results showed significant increased (P< 0.05) in the serum concentrations of reproductive hormones. Histological assessment results which further confirmed the above findings were seen in all groups supplemented with Zn and L-carnitine implicating their beneficial effect on reproductive potential. Conclusion: The combined use of zinc and L-carnitine has an enhanced effect which improves follicular growth and hormonal balance compared to either used alone. Their synergistic action assists ovarian function by enhancing energy metabolism and decreasing oxidative stress, indicating its great potential for the management of ovarian dysfunction.
Keywords: Folliculogenesis, Zn, L-carnitine, Fertility hormones, Oxidative stress
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© 2025 Published by Laxmi Memorial Education Trust. This is an open-access article under CC BY 4.0 license. (https://creativecommons.org/licenses/by/4.0/)
Lamyaa Abdulridha Fadhil. Impact of Oral Zinc and L-Carnitine Supplementation on Follicles Growth and Endocrine Fertility Regulation in Female Albino Mice. AJ J Med Sci 2025;2(4):170-176.