Volume: 2 Issue: 1
Year: 2025, Page: 11-16, Doi: https://doi.org/10.71325/ajjms.v2i1.25.5
Received: Jan. 20, 2025 Accepted: Feb. 28, 2025 Published: March 31, 2025
Introduction and Aim: Diabetic foot ulcer (DFU) is a major complication in diabetics and is associated with a high risk of amputation, morbidity and mortality. Topical silver nanoparticle dressings are increasingly being utilized for treatment of acute DFU’s. The aim of the study is to compare the effect of topical silver colloid nanoparticle dressing wound in comparison to conventional dressing in acute DFU’s. Materials and Methods: This is Tertiary care Hospital based comparative prospective observational study of 9 years. Patients with Acute DFU’s were split into two groups with 400 in each. Group A includes conventional(control) dressing, Group B includes silver colloid nanoparticle dressing. A standard format was used for collection of data regarding DFU’s and other necessary parameters. Results: The ulcer area significantly decreased in the silver colloid nanoparticle group compared to the conventional saline group. By the end of 4 weeks, Ulcers measuring less than 10cm2 had 100% and 68.4% ulcers healing in silver colloid nanoparticle and conventional group respectively, whereas in ulcers measuring more than 10cm2 to 25cm2 had healing at 4 weeks 67.5% and 45.34% respectively. Patients with more than 25cm2 had a protracted course about 8-12 weeks in respective groups but healing was comparatively better in silver nanoparticle group. Conclusion: Silver based nanoparticle dressings had a faster rate of wound healing in superficial acute DFU’s with Meggitt Wagner’s grade I and II. Patients in our trial group who received ionic silver-based dressings reached the end point sooner and either had an ulcer that healed spontaneously with regular dressing or was ready for SSG. We do not recommend silver dressing for acute DFU’s with larger surface area in view of toxicity of silver ion. The use of silver ion dressing should be case based according to severity and clinical application.
Keywords: Diabetic foot ulcer, Silver colloid nanoparticle dressing, Conventional dressing, Wound healing
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© 2025 Published by Laxmi Memorial Education Trust. This is an open-access article under CC BY 4.0 license. (https://creativecommons.org/licenses/by/4.0/)
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