Volume: 2 Issue: 2
Year: 2025, Page: 77-82, Doi: https://doi.org/10.71325/ajjms.v2i2.25.24
Received: April 24, 2025 Accepted: May 20, 2025 Published: July 17, 2025
Background: Rheumatoid arthritis (RA) is a long-lasting inflammatory condition characterized by inflammation of the synovial membrane in the joints and may lead to reduced mobility, joint deformities, and disability. The development of precise diagnostic tools remains a persistent challenge in the effective management of the disease, aiming to improve patient outcomes. The present study was conducted to assess the diagnostic values of serum biomarkers among rheumatoid patients. Materials and Methods: An analytical case-control study conducted at Kosti Teaching Hospital included 100 rheumatoid patients as the case group and 100 healthy individuals as controls. Blood samples were collected and analyzed for the C-reactive protein (CRP), rheumatoid factor (RF) erythrocyte sedimentation rate (ESR), C-reactive protein /albumin ratio (CAR), Calcium, parathyroid hormone (PTH) and Albumin. Data was analyzed using SPSS version (27). Results: Our findings indicated that levels of RF, PTH, ESR, and CAR were significantly elevated in cases compared to controls, (P<0.001). Additionally, CAR and CRP exhibited a strong positive correlation with disease activity (r=0.915, P=0.000 and r=0.850, P=0.000, respectively), but showed no correlation with disease duration (r=0.069, P=0.495, and r=0.075, P=0.461). Serum calcium levels did not correlate with disease activity or duration. Sensitivity and specificity of CAR (sen: 97% and spec: 98%), CRP (sen:96% and spec: 91%) ESR (sen: 54% and spec: 93%), ALB (sen: 92% and spec: 87%), PTH (sen: 27% and spec: 98%). Conclusion: Elevated levels of RF, ESR, CRP, CAR, and PTH have been linked to rheumatoid arthritis. Furthermore, CAR has the potential to serve as a cost-effective and readily implementable diagnostic biomarker for rheumatoid arthritis.
Keywords: Rheumatoid, Inflammation, Calcium, Albumin, Biomarkers
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© 2025 Published by Laxmi Memorial Education Trust. This is an open-access article under CC BY 4.0 license. (https://creativecommons.org/licenses/by/4.0/)
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